𝔖 Bobbio Scriptorium
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Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy

✍ Scribed by A. R. Zanetti; E. Tanzi; L. Romano; P. Vigano; A. Cargnel; S. Hojvat; A. J. Zuckerman

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
531 KB
Volume
32
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast‐derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti‐a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti‐a antibody after active immunisation raises important issues of early protection against infection.

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