Kinetics of ajmaline disposition and pharrnacologic response in beagle dogs
โ Scribed by Masato Yasuhara; Yukiya Hashimoto; Katsuhiko Okumura; Ryohei Hori; Tsunetaro Sakurai; Chuichi Kawai
- Book ID
- 112473853
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 870 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1573-8744
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The absorption and disposition kinetics of HI-6 were determined in Beagle dogs given single doses (25 mg kg-') of the drug by the intravenous, intramuscular, and oral routes. Concentrations of the oxime in plasma and urine were measured by HPLC. A twocompartment open model was used to describe the d
The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were approximat