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Kinetics of action of two leukotriene antagonists on guinea pig ileum

✍ Scribed by Martin C. Holroyde; Anant M. Ghelani


Book ID
115877810
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
336 KB
Volume
90
Category
Article
ISSN
0014-2999

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The effects of 4-aminopyridine (4-AP) and of taurine on the guinea pig ileum were examined. Four-AP increases the basal activity from 1.3 to 6.45 cm2/min. This effect is atropine-sensitive and calcium-dependent. Taurine counteracts the effects of 4-AP on muscle contracture in a concentration-depende