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Kinetics of a novel blood pool agent (MP-2269) with persistent high relaxivity for MR angiography

✍ Scribed by Hofman, Mark B.M.; Adzamli, Kofi; Allen, John S.; Fischer, Stefan E.; Brown, Jeffrey J.; Adams, Max D.; Wickline, Samuel A.; Lorenz, Christine H.


Book ID
122658405
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
340 KB
Volume
5
Category
Article
ISSN
1076-6332

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Synthesis and preliminary evaluation of
✍ Rebecca A. Wallace; Joe P. Haar Jr.; Donald B. Miller; Steven R. Woulfe; John A. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 724 KB

## Abstract A nonaromatic, small‐molecule, gadolinium(3+)‐chelate code named MP‐2269 was synthesized and evaluated in animals as a potential MR contrast agent for blood pool. The ligand of MP‐2269 was prepared by conjugating a lipophilic, albumin‐binding moiety, 4‐pentylbicyclo[2.2.2]octane‐1‐carbo