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Kinetics and Mechanisms of Activation of α-Amino Acid Ester Prodrugs of Camptothecins

✍ Scribed by Song, Lin; Bevins, Robert; Anderson, Bradley D.

Book ID
124161859
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
347 KB
Volume
49
Category
Article
ISSN
0022-2623

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Amino acid esters of phenols as prodrugs: Synthesis and stability of glycine, β-aspartic acid, and α-aspartic acid esters of p-acetamidophenol
✍ Ildiko M. Kovach; Ian H. Pitman; Takeru Higuchi 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 670 KB

pH-rate profiles were calculated for the hydrolysis of the glycine (II), P-aspartic acid (III), and a-aspartic acid (IV) esters of pacetamidopbenol (I) at 25" and = 1.0 M. The hydrolysis of esters I1 and 111 occurred predominantly uia intermolecular reactions involving water, hydroxide ion, and the