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Kinetics and Mechanism of Certain Acetylation Reactions with Acetamide/Oxychloride in Acetonitrile under VilsmeierHaack Conditions

✍ Scribed by Marri Venkateswarlu; Mukka Satish Kumar; Soma Ramgopal; Kamatala Chinna Rajanna; Utkoor Umesh Kumar; Kusampally Uppalaiah; Pondichery Kuppuswamy Saiprakash

Publisher: John Wiley and Sons
Year: 2011
Tongue: German
Weight: 354 KB
Volume: 94
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201100178

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✦ Synopsis

Abstract

VilsmeierHaack (VH) acetylation reactions with benzaldehydes or acetophenones in MeCN followed second‐order kinetics and afforded acetyl derivatives under kinetic conditions, irrespective of the nature of the oxychloride (SOCl~2~ or POCl~3~) used for the preparation of the VH reagent along with acetamide. The present finding contributes to the understanding of the nature of the reactive species of the VH reagent as well as of the acetylation mechanism.

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