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Kinetics and Mechanism for the Reaction of Cysteine with Hydrogen Peroxide in Amorphous Polyvinylpyrrolidone Lyophiles

✍ Scribed by Dayong Luo; Bradley D. Anderson

Book ID: 106492867
Publisher: Springer US
Year: 2006
Tongue: English
Weight: 706 KB
Volume: 23
Category: Article
ISSN: 0724-8741
DOI: 10.1007/s11095-006-9052-z

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## Abstract A mechanism for the oxidation of cysteine by hydrogen peroxide has been proposed by Luo et al. (__J Pharm Sci__, 2005, 94, 304–316): rapid equilibrium to form cysteinate (CS^−^), followed by irreversible oxidation of CS^−^ by H~2~O~2~ to give cysteine sulfenic acid (CSOH), and nucleophi