Kinetics and factors affecting stability of methylprednisolone in aqueous formulation

✍ Scribed by M. I. Amin; J. T. Bryan

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 424 KB
• Volume: 62
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600621106

✦ Synopsis

was believed to have been formed alter elimination of hydrobromide from this displacement intermediate.

Sarnour BI trl. (12) reported that some alkoxymethyl derivatives of 1 were etrective anticonvulsants. Therefore. it was of interest to test sonic alkyl derivatives for anticonvulsant activity. Three compounds rcprcsenting three different chemical structures were studied. Results of the biological restings showed that VI. XIV. and XVII, when suspended in 107; acacia and given orally, exhibited no activity against pcntylCnctctrazol-itiduced seizures in mice at a dose of I g./kg. According to the acute toxicity studies, these compounds appeared to be relatively nontoxic. None of the aiiiinals died a5 a result of oral administration at a 2-g./kg. dose level. which was the maximum amount of the compound that could be suspended in an appropriate volume of lo'!< acacia. REFERENCES ( I ) "Dictionary of Organic Compounds." vol. 4, J. R. A.