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Kinetically Stable Complexes in Water: The Role of Hydration and Hydrophobicity

✍ Scribed by Biros, Shannon M.; Ullrich, Elke C.; Hof, Fraser; Trembleau, Laurent; Rebek, Julius

Book ID
121479386
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
324 KB
Volume
126
Category
Article
ISSN
0002-7863

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A measurement of the hydrophobic character of the drug substrate, henceforward termed as the hydrophobic effect (HE), to complex stability is established through the observed linear correlation of the free energy of 1:1 complex formation (Ξ”G K 11 = -RTlnK 11 x ) with the free energy of inherent dru