Kinetic study of ligand exchange reaction between 99mTc-glucoheptonate and N-benzyl-N-methyl-piperazinyl-bis-(aminoethanethiol) (BPA-BAT)
✍ Scribed by Hank F. Kung; Bo-Li Liu; Sangren Pan
- Book ID
- 103922150
- Publisher
- Elsevier Science
- Year
- 1989
- Weight
- 436 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0883-2889
No coin nor oath required. For personal study only.
✦ Synopsis
In order to explore the exchange reaction between the 99mTc-GH (glucoheptonate)
and N,S, (BAT) ligands, as a common method for the preparation of 99mTc complexes, detailed kinetic studies were evaluated.
This paper presents our preliminary results on kinetic studies of the exchange reaction at different ligand concentrations, as well as the determination of the overall formation rate constants and the fractional rate constants for each stereoisomer.
The ligand exchange reaction between %"TcCrH and a stronger N,S, ligand, BPA-BAT-(N'-benzyl-N-methyl-piperazinyl derivative of bis-(aminoethanethiol), racemic mixture) is a second order reaction. The average rate constant (formation constant, k) of this ligand exchange reaction was determined: k = 3.71 x lo3 M-i min'.
Based on the ratio of %"Tc synvs the anti-isomer at equilibrium (1.229 k 0.026), the same rate constant for the formation of individual isomers was calculated: k,,, = 2.045 x IO3 M-' min