Binding of phosphorus-containing inhibit
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Jian Shen; John Wendoloski
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Article
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2008
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Cold Spring Harbor Laboratory Press
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English
β 839 KB
## Abstract Zinc endopeptidase thermolysin can be inhibited by a series of phosphorusβcontaining peptide analogues, CbzβGlyβ__Ο__(PO~2~)βXβLeuβYβR (ZG^P^(X)L(Y)R), where X = NH, O, or CH~2~; Y = NH or O; and R = Leu, Ala, Gly, Phe, H, or CH~3~. The affinity correlation as well as an Xβray crystallo