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Kinetic Studies of the Binding of Acridinecarboxamide Topoisomerase Poisons to DNA: Implications for Mode of Binding of Ligands with Uncharged Chromophores

✍ Scribed by Wakelin, Laurence P. G.; Adams, Adrienne; Denny, William A.


Book ID
125953744
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
89 KB
Volume
45
Category
Article
ISSN
0022-2623

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## Abstract A temperature‐jump relaxation study of the interaction of tilorone with different polynucleotides and DNA has been performed. A single relaxation time, attributed to the intercalation step, has been observed in the case of poly[d(A‐T)]Β·poly[d(A‐T)], poly[d(A‐C)]Β·poly[d(G‐T)], poly[d(G‐C