Kinetic solvent deuterium isotope effect on the oxygenation of N,N-dimethylaniline with the pig liver microsomal fad-containing monooxygenase
✍ Scribed by Ken Fujimori; Masafumi Yaquchi; Akihiro Mikami; Takaharu Matsuura; Naomichi Furukawa; Shigeru Oae; Takashi Iyanagi
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 228 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Both the maximum we.Locity and the Michae.U canotati od Xhe oxy,qena.tion od N,N-dimeXhyfaniLLne with the pig k!iveh nichodomal FAV-contain&y monooxggenane (EC J.14.13.b) to N,N-dimtihyLanXine N-oxide appewt 1.7 Qoldn yteaakt in aqueoti bu6de.4 ooLution 06 pff 7.4 than thobe i.n deutetium oxide buddti no&&ion od pU 7.4. Liver microsomal FAD-containing monooxygenase (EC 1.14.13.8), which was first isolated and characterized by Ziegler and coworkers, 1) is known to add oxygen to xenobiotic amines (cq.1). 1) The enzyme contains flavin adenine