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Kinetic resolution of racemic carboxylic acids and alcohols with homochiral alcohols and carboxylic acids, respectively, and the Mukaiyama or Palomo reagents

✍ Scribed by Angel Mazón; Carmen Nájera; Miguel Yus; Andreas Heumann


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
689 KB
Volume
3
Category
Article
ISSN
0957-4166

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Preliminary investigations focused on the kinetic resolution of (+/-)-alpha-acetoxy mandelic carboxylic acid chloride with isopropyl SuperQuat and isopropyl Evans' homochiral auxiliaries. The addition of 2 equiv. of the acid chloride to the lithium salts of the auxiliaries (SuperQuat and Evans') at