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Kinetic Resolution of Propargylic and Allylic Alcohols by Candida antarctica Lipase (Novozyme 435).

✍ Scribed by Cristiano Raminelli; Joao V. Comasseto; Leandro H. Andrade; Andre L. M. Porto


Publisher
John Wiley and Sons
Year
2005
Weight
23 KB
Volume
36
Category
Article
ISSN
0931-7597

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Lipase B from Candida antarctica (CAL-B) catalyses the highly enantioselective (E > 200) transesterification of some 1-biaryl-2-yl-, -3-yl-, and -4-ylethanols and -propan-1-ols, as well as 1-(o-, m-, and p-pyridylphenyl)ethanols, 6, with vinyl acetate, Kazlauskas rule being obeyed in all cases. meta