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Kinetic resolution of 2-chloro-3,3,3-trifluoropropanoic acid esters catalyzed by lipase from Candida rugosa

✍ Scribed by Yuryev, Ruslan; Ivanova, Marta; Daskalova, Valentina; Müller, Rudolf


Book ID
121400165
Publisher
Informa plc
Year
2011
Tongue
English
Weight
294 KB
Volume
29
Category
Article
ISSN
1024-2422

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Lipase-catalyzed kinetic resolution of 3
✍ Sadao Tsuboi; Nobuyuki Yamafuji; Masanori Utaka 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 289 KB

Reduction of 3-chloro-2-oxoalkanoates 1 with NaBH4 gave predominantly syn-3-chloro-2-hydroxyalkanoates 2 (synlanti=9119-9911) in 50--97% yields. Resolution of syn-2 by lipase-catalyzed transesterification gave (2S,3S)-2 and (2R,3R)-2-acetoxy-3chloroalkanoates (2R,3R)-3. Total synthesis of (-)-dispar