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Kinetic profiles of tianeptine and its MC5metabolite in plasma, blood and brain after single and chronic intraperitoneal administration in the rat

✍ Scribed by W. Couet; J. Girault; F. Latrille; C. Salvadori; J. B. Fourtillan

Book ID
113006749
Publisher
Springer-Verlag
Year
1990
Tongue
English
Weight
575 KB
Volume
15
Category
Article
ISSN
0378-7966

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## Abstract D, L‐3‐hydroxy‐3‐ethyl‐3‐phenylpropanamide (HEPP) is a synthetic drug with anticovulsant effects in a variety of seizure models. HEPP pharmacokinetics was studied after single 50 mg kg^βˆ’1^ intravenous (IV), intraperitoneal (IP), and oral (PO) administration in male albino Wistar rats. T