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Kinetic modeling of the serotonin 5-HT1B receptor radioligand [11C]P943 in humans

✍ Scribed by Gallezot, Jean-Dominique; Nabulsi, Nabeel; Neumeister, Alexander; Planeta-Wilson, Beata; Williams, Wendol A; Singhal, Tarun; Kim, Sunhee; Maguire, R Paul; McCarthy, Timothy; Frost, J James


Book ID
109871232
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
737 KB
Volume
30
Category
Article
ISSN
0271-678X

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## N1-(111C]-Methyl>2-Br-LSD ([llC] -MBL) has been developed as a positron emission tomography (PET) imaging agent for serotonin 5-HT2 receptors. In vitro receptor binding assays with nonradioactive MBL show high-affinity binding to serotonin 5-HT2 receptors (Ki = 0.5 nM), a secondary interaction