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Kinetic modeling of the renal excretion of iodopyracet in the dog

✍ Scribed by Peter Hekman; Cees A. M. van Ginneken

Book ID
112472314
Publisher
Springer
Year
1982
Tongue
English
Weight
733 KB
Volume
10
Category
Article
ISSN
1573-8744

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Physiologically based pharmacokinetic mo
Physiologically based pharmacokinetic model for the renal clearance of iodopyracet and the interaction with probenecid in the dog
✍ Frans G. M. Russel; Alfons C. Wouterse; Cees A. M. Van Ginneken πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 704 KB

Plasma kinetics and renal excretion of iodopyracet (3\*0g, adminstered i.v.) with and without concomitant administration of probenecid were studied in the beagle dog. Pharmacokinetic analysis revealed that tubular secretion is the predominant route of excretion, and that secretion is inhibited by pr