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Kinetic Isotope Effects in a C−H Bond Dissociation by the Iron-Oxo Species of Cytochrome P450

✍ Scribed by Yoshizawa, Kazunari; Kagawa, Yoshihisa; Shiota, Yoshihito


Book ID
121196279
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
154 KB
Volume
104
Category
Article
ISSN
0022-3654

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Kinetic isotope effects in the intramole
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An internal competition was used to estimate the kinetic isotope effect of an intramolecular metal carbene C-H insertion reaction alpha to a nitrogen atom. A stereoelectronic effect is proposed to explain the difference in magnitude of the observed KIEs for cis and trans diastereomers.