The effects of the concentrations of LiCI, NaCl, KC1, CsCl, NaZCO3, BaC12, and Me4NCI on the rates of reactions of hydroxide ion with ionized N-hydroxyphthalimide (NHP) at 30Β°C and in a HzO-MeCN solvent containing 98%, v/v, HzO reveal a nonlinear increase in observed rate constants with increase in
Kinetic evidence for the unusual path in the hydrolysis of amides. pH-rate profile for N-trifluoroacetylindole
β Scribed by Antonio Cipiciani; Paolo Linda; Gianfranco Savelli
- Book ID
- 112125516
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1978
- Tongue
- English
- Weight
- 88 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-152X
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## Abstract Recent theoretical studies of the alkaline hydrolysis of the amide bond have indicated that the nucleophilic attack of the hydroxide ion at the carbonyl carbon of the amide group is rate limiting. This is shown to be inconsistent with a large amount of experimental observations where th
## Abstract Kinetic study on the cleavage of __N__βphenylphthalimide (NPhPT) in the presence of 0.05 M NH~2~NH~2~ and mixed H~2~OβCH~3~CN solvents reveals the occurrence of reaction scheme equation image where A, B, C, C~1~, An, E, and F represent NPhPT, __o__βCO^β^~2~C~6~H~4~CONHC~6~H~5~, __o__β