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Kinetic evidence for the occurrence of general acid-base catalysis in N-methylhydroxylaminolysis of N-ethoxycarbonylphthalimide (NCPH)

✍ Scribed by M. Niyaz Khan

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 160 KB
Volume: 29
Category: Article
ISSN: 0538-8066
DOI: 10.1002/(sici)1097-4601(1997)29:9<647::aid-kin1>3.0.co;2-u

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✦ Synopsis

General acid-base (GA-GB) catalysis appears to be the ubiquitous feature of many enzyme-catalyzed reactions [1]. Since the awareness of this fact, a huge amount of kinetic work has been carried out on enzyme model reactions to understand the mechanism(s) of these catalyses [2]. Although many fine details of the mechanism(s) of these catalyses

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Kinetic evidence for the occurrence of k

Kinetic evidence for the occurrence of kinetically detectable intermediates in the cleavage of N-ethoxycarbonylphthalimide under N-methylhydroxylamine buffers

✍ M. Niyaz Khan 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB

## Abstract The kinetics of the aqueous cleavage of __N__‐ethoxycarbonylphthalimide (NCPH) in CH~3~NHOH buffers of different pH reveals that the cleavage follows the general irreversible consecutive reaction path NCPH $\buildrel{k\_{1\,{\rm obs}}}\over\longrightarrow$ ENMBC $\buildrel{k\_{2\,{\rm