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Kinetic evidence for a ligand-binding-induced conformational transition in the T cell receptor

✍ Scribed by Gakamsky, D. M.; Lewitzki, E.; Grell, E.; Saulquin, X.; Malissen, B.; Montero-Julian, F.; Bonneville, M.; Pecht, I.

Book ID
121760017
Publisher
National Academy of Sciences
Year
2007
Tongue
English
Weight
724 KB
Volume
104
Category
Article
ISSN
0027-8424

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## Abstract By using a lactose permease mutant containing a single Cys residue in place of Val 331 (helix X), conformational changes induced by ligand binding were studied. With right‐side‐out membrane vesicles containing Val 331 β†’ Cys permease, lactose transport is inactivated by either __N__‐ethy