✦ LIBER ✦
Kinetic Data for the Transmetalation/Reductive Elimination in Palladium-Catalyzed Suzuki–Miyaura Reactions: Unexpected Triple Role of Hydroxide Ions Used as Base
✍ Scribed by Dr. Christian Amatore; Dr. Anny Jutand; Gaëtan Le Duc
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 379 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0947-6539
No coin nor oath required. For personal study only.
✦ Synopsis
Dedicated to Professor Marc Julia
, which generates ArAr' and a Pd 0 species. Conversely, the base OH À disfavors the reaction by formation of the unreactive anionic Ar'B(OH) 3
À . As a consequence of these antagonistic effects of OH À , the overall reactivity is controlled by the concentration of OH À and passes through a maximum as the concentration of OH À is increased. Therefore, the base favors the rate-determining transmetalation and unexpectedly also the reductive elimination.