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Kinetic Constants for Blood—Brain Barrier Amino Acid Transport in Conscious Rats

✍ Scribed by L. P. Miller; W. M. Pardridge; L. D. Braun; William H. Oldendorf

Book ID
111173411
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
563 KB
Volume
45
Category
Article
ISSN
0022-3042

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✍ Quentin R. Smith; Seiji Momma; Masaki Aoyagi; Stanley I. Rapoport 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 784 KB

Neutral amino acid (NAA) transport across the blood-brain barrier was examined in pentobarbitalanesthetized rats with an in situ brain perfusion technique. Fourteen of 16 plasma NAAs showed measurable affinity for the cerebrovascular NAA transport system. Values of the transport constants (V,,,, K,,