Kinetic components of the gating currents of human cardiac L-type Ca2+channels
β Scribed by Ira R. Josephson
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 442 KB
- Volume
- 433
- Category
- Article
- ISSN
- 0031-6768
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π SIMILAR VOLUMES
Ca(2+)-induced inactivation of L-type Ca2+ channels is proposed as an important negative feedback mechanism regulating Ca2+ entry. Here, for the first time, evidence for modification of heart L-type Ca2+ channel activity by cytoplasmic calcium is provided from excised inside-out membrane patches. Ba
## Abstract Sodiumβchannel behavior has been modeled in order to determine the answer to the following question: How large must a population of βonβoffβ Sodium pores be before the inherently random behavior of the individual channels becomes smoothed to yield the expected gating currentβconductance