Kinetic characteristics of interaction of conotoxin with N-type Ca2+channels in rat hippocampal neurons
β Scribed by A. I. Fisyunov; O. A. Krishtal
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 339 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0090-2977
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Electrophysiological studies of the effects of test compounds on ion channel currents have been useful in the identification of novel therapeutic agents. Here, we examined the use of cultured superior cervical ganglion (SCG) neurons as a model system for the electrophysiological evaluation of N-type
Previously it was found that the amplitude of Ca currents in CA1 hippocampal neurons increases after adrenalectomy (ADX) of young adult rats. Preliminary data suggested that this effect of ADX is age-dependent. In the present study we therefore investigated the effect of ADX on Ca currents in three
## Abstract Mossy fibers (axons arising from dentate granule cells) form large synaptic contacts exclusively onto the proximal apical dendrites of CA3 pyramidal neurons. They can generate large synaptic currents that occur in close proximity to the soma. These properties mean that active conductanc
## Abstract Vascular endothelial growth factor (VEGF) protects neurons against ischemic injury. An overload of intracellular calcium ions (Ca^2+^) caused by the excessive release of glutamate is widely considered to be one of the molecular mechanisms of ischemic neuronal death. In the present study