Kinetic Analysis of the Interactions between Troponin C and the C-terminal Troponin I Regulatory Region and Validation of a New Peptide Delivery/Capture System used for Surface Plasmon Resonance

Kinetic analysis of the interactions bet

Kinetic analysis of the interactions between Troponin C (TnC) and Troponin I (TnI) binding peptides: evidence for separate binding sites for the ‘structural’ N-terminus and the ‘regulatory’ C-terminus of TnI on TnC

✍ Brian Tripet; Gregory De Crescenzo; Suzanne Grothe; Maureen O'Connor-McCourt; Ro 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB 👁 1 views

The Ca(2+)/Mg(2+)-dependent interactions between TnC and TnI play a critical role in regulating the 'on' and 'off' states of muscle contraction as well as maintaining the structural integrity of the troponin complex in the off state. In the present study, we have investigated the binding interaction