Kinetic analysis of stimulus-induced insulin release in thyrotoxic and normal subjects

✍ Scribed by Jayendra H. Shah; Dabir S. Viswanath; Sudhir S.J. Batchu

• Book ID: 103928678
• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 356 KB
• Volume: 14
• Category: Article
• ISSN: 0895-7177
• DOI: 10.1016/0895-7177(90)90244-h

✦ Synopsis

We performed a kinetic analysis of the experimental data obtained durina the 25 aram intravenous alucose tolerance tests in 10 thyrotixic (five males and five-females), and age and sex matched 10 normal subjects. Blood samples were collected before (zero time) and after a glucose pulse at one minute intervals between zero and seven minutes, and at five minute intervals between 10 and 60 minutes for glucose and insulin determinations.

The kinetic analysis of the data revealed that glucose sensitivity of the pancreatic beta cell to induce insulin release was markedly increased in thyrotoxic subjects.

As compared to normal subjects, the rate of insulin release was significantly accelerated in thyrotoxic subjects. The insulin delivery in response to glucose was biphasic in both normal and thyrotoxic subjects.

Despite higher insulin levels, the fractional and metabolic clearance rate of glucose was similar in thyrotoxic and normal subjects.

These findings suggest that the peripheral tissue sensitivity to insulin is decreased in thyrotoxic subjects.