Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates
β Scribed by Franz Worek; Nadine Aurbek; Marianne Koller; Christian Becker; Peter Eyer; Horst Thiermann
- Book ID
- 113488229
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 835 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0006-2952
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Methamidophos (CH3O(NH2)P(O)SCH3) and phosphoramidates, with the general structure RO(NH2)P(O)OC6H4-p-NO2, in which R = C2H5, C1CH2CH2, FCH2CH2 and F3CCH2, as well as (NH2)2P(O)OC6H4-p-NO2 were synthesized to investigate the relationship between the rates of inhibition and of spontaneous reactivatio
Defense. Aherdeen Proving Ground. MD 21010-5425. USA K e y word5 organophosphinate, orgdnophosphonatc. harin, oxiiiieq ,icetylcholinesterasc. rexti\dtioii. pretrc'itment The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the orga