Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa

Trichostatin A, a histone deacetylase in

Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells

✍ Hua Xiong; Wan Du; Yan-Jie Zhang; Jie Hong; Wen-Yu Su; Jie-Ting Tang; Ying-Chao 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 882 KB

## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator