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Kinetic analysis of [11C]GSK189254, a novel radioligand for the H3 receptor in humans using positron emission tomography (PET)

✍ Scribed by Vincent J. Cunningham; S. Ashworth; E.A. Rabiner; C. Plisson; G.E. Searle; R.N. Gunn; M. Laruelle


Book ID
118491181
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
82 KB
Volume
41
Category
Article
ISSN
1053-8119

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The cocaine analogue P-CIT-FE (N-(2-fluoroethyl)-2~-carbomethoxy-3~-(4-iodopheny1)nortropane) was labeled with ' lC for positron emission tomography (PET) studies of the dopamine transporter. After intravenous administration to a cynomolgus monkey, ["CIP-CIT-FE accumulated in the striatum with a str