Kinase Data Mining: Dealing with the Information (Over-)Flow

✍ Scribed by Knut Eis; Stuart J. Ince; Carsten Jahn; Rolf Jautelat; Vladimir Katchourovsky; Georg Kettschau; Rolf Woloszczak

• Book ID: 101822841
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 111 KB
• Volume: 6
• Category: Article
• ISSN: 1439-4227
• DOI: 10.1002/cbic.200400154

✦ Synopsis

K. Eis et al. * Kinase inhibition (typically IC 50 s in nm), * Cellular assay data (typically IC 50 s in mm), * Physicochemical data (e.g. solubility, pK a , log P), * Data on 3D structural analysis in conjunction with proteins, the *.pdb files of which are referenced, * Orientation (if 3D data are available, the structure is oriented in such a way that the hinge region of the protein is located on the left of the structure field), * Literature, patent, or conference references (for external data), * Ownership information (companies or/and institutions holding patents), * Status of clinical investigation, * Originator information (e.g. the originating Schering chemist, or a commercial vendor), * Group assignment (allowing for easy subset selection within a specific query, for example, "structures with IC 50 values", or "external compounds" in order to get an overview of competitor activities).