Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
β Scribed by Elisa Greggio; Shushant Jain; Ann Kingsbury; Rina Bandopadhyay; Patrick Lewis; Alice Kaganovich; Marcel P. van der Brug; Alexandra Beilina; Jeff Blackinton; Kelly Jean Thomas; Rili Ahmad; David W. Miller; Sashi Kesavapany; Andrew Singleton; Andrew Lees; Robert J. Harvey; Kirsten Harvey; Mark R. Cookson
- Book ID
- 113812022
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 1011 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0969-9961
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## Abstract Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes the formation of sphingosine 1βphosphate (S1P), an important lipid mediator, which regulates fundamental biological processes. Here, we provide evidence that SphK is required for the achievement of cell growth arrest a