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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

✍ Scribed by Elisa Greggio; Shushant Jain; Ann Kingsbury; Rina Bandopadhyay; Patrick Lewis; Alice Kaganovich; Marcel P. van der Brug; Alexandra Beilina; Jeff Blackinton; Kelly Jean Thomas; Rili Ahmad; David W. Miller; Sashi Kesavapany; Andrew Singleton; Andrew Lees; Robert J. Harvey; Kirsten Harvey; Mark R. Cookson


Book ID
113812022
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
1011 KB
Volume
23
Category
Article
ISSN
0969-9961

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Sphingosine kinase activity is required
✍ Elisabetta Meacci; Francesca Nuti; Chiara Donati; Francesca Cencetti; Marta Farn πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 420 KB

## Abstract Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes the formation of sphingosine 1‐phosphate (S1P), an important lipid mediator, which regulates fundamental biological processes. Here, we provide evidence that SphK is required for the achievement of cell growth arrest a