KIM185, a monoclonal antibody to CD18 which induces a change in the conformation of CD18 and promotes both LFA-1- and CR3-dependent adhesion

Induction of cell-associated interleukin

Induction of cell-associated interleukin 1 through stimulation of the adhesion-promoting proteins LFA-1 (CD11a/CD18) and CR3 (CD11b/CD18) of human monocytes

✍ Christine Couturier; Nicole Haeffner-cavaillon; Laurence Weiss; Elisabeth Fische 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 666 KB

## Abstract Serum‐free culture of human monocytes in the presence of monoclonal antibodies to the LFA‐1 α chain (CD11a), CR3 α chain (CD11b) or β chain (CD18) bound to Sepharose induced the dose‐dependent production of cell‐associated interleukin (IL) 1 activity and of IL 1α and IL 1β antigens, but