Killing of antigen-reactive B cells by class II- restricted, soluble antigen–specific CD8+ cytolytic T lymphocytes
✍ Scribed by Shinohara, Nobukata; Watanabe, Motoo; Sachs, David H.; Hozumi, Nobumichi
- Book ID
- 109757214
- Publisher
- Nature Publishing Group
- Year
- 1988
- Tongue
- English
- Weight
- 466 KB
- Volume
- 336
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/336481a0
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Antigenic stimulation with exogenous soluble proteins induces cytotoxic T lymphocytes (CTL) recognizing antigenic peptides presented on class II major histocompatibility complex (MHC) molecules. Such CTL have been shown to lyse preferentially B cells expressing immunoglobulin receptors reactive with
## Abstract The requirements for the conversion of CD8^+^ memory T cells into effector class I major histocompatibility complex (MHC) K^d^−restricted cytotoxic T (T~c~) cells __in vitro__ have been studied. Purified CD8^+^splenocytes from influenza A/WSN‐primed BALB/c (H‐2^d^) mice stimulated with