## Abstract DR4 (TRAIL‐R1), a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL). Although three other TRAIL receptors DR5, DcR1, and Dc
✦ LIBER ✦
KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene
✍ Scribed by Wu, Gen Sheng; Burns, Timothy F.; McDonald, E. Robert; Jiang, Wen; Meng, Ray; Krantz, Ian D.; Kao, Gary; Gan, Dai-Di; Zhou, Jun-Ying; Muschel, Ruth
- Book ID
- 109918324
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 530 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1061-4036
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## Abstract DNA damage is known to be an initiator of neuronal death in neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. The mechanism linking DNA damage and neuronal death is not completely understood. Here, we delineate the mechanism by which neuronal death evoked by DNA