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Kidney function in male and female rats chronically exposed to potassium dichromate

✍ Scribed by A. Vyskočil; C. Viau; M. Čížková; G. Truchon

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
173 KB
Volume
13
Category
Article
ISSN
0260-437X

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✦ Synopsis

Male and female Wistar rats were given 25 mg I-' chromium (as potassium dichromate) in drinking water for 6 months. Lactate dehydrogenase, lysozyme, total proteins, Kacetyl-P-D-glucosaminidase, albumin and P2-microglobulin (P,-m) were measured in 24-h urine after 3 and 6 months of exposure. Body and kidney weight and chromium excretion were also examined.

Except for the chromium excretion, no statistically significant changes were observed in the exposed male rats. In female rats there were significant increases in the urinary excretion of albumin after 3 and 6 months of exposure and the urinary excretion of P2-m after 3 months of exposure.

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