✦ LIBER ✦

Kidney development branches out

✍ Scribed by Dressler, Gregory R.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 52 KB
Volume: 24
Category: Article
ISSN: 0192-253X
DOI: 10.1002/(sici)1520-6408(1999)24:3/4<189::aid-dvg1>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

For more than 40 years now, the developing kidney has served as a model paradigm for epithelial-mesenchymal interactions. The principles of inductive signaling, epithelial cell differentiation, and pattern formation are now being addressed with modern genetic and biochemical tools. In addition to the mammalian kidney organ culture model, both zebrafish and Xenopus laevis demonstrate great potential for investigating the molecular mechanisms of kidney organogenesis within a whole organism. In this review, the papers presented in this special issue are discussed with respect to recent progress in the renal development field. Coincidentally, it has become increasingly clear that progress made in renal development can impact our understanding of the genetic basis of disease.

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