Kidney cadmium as compared to other markers of cadmium exposure in workers at a secondary metal smelter
✍ Scribed by Jimmy Börjesson; Lars Gerhardsson; Andrejs Schütz; Roland Perfekt; Sören Mattsson; Staffan Skerfving
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 199 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0271-3586
No coin nor oath required. For personal study only.
✦ Synopsis
Background The aim of the study was to evaluate whether cadmium concentrations in kidney (K-Cd), blood (B-Cd) or urine (U-Cd) could reveal previous occupational cadmium exposure at a metal smelter. Methods The study included 90 smelters and 35 controls (B-Cd and U-Cd determination). In a subgroup (N 33), K-Cd was also determined. Results B-Cd (median 4.6; range 0.5±53 nmol/L), U-Cd (0.29; 0.04±1.9 mmol/mol creatinine) and K-Cd (14; 3±61 mg/g wet weight) were similar to reported concentrations in the general Swedish population. In the subgroup, signi®cant associations (P`0.001) were obtained between B-Cd and K-Cd (r 0.70), U-Cd and K-Cd (r 0.60) and between U-Cd and B-Cd (r 0.62). Multiple regression analyses revealed smoking as the major predictor of K-Cd, B-Cd, and U-Cd. B-Cd and U-Cd were both associated with the duration of employment at the smelter. Conclusions There was no statistically signi®cant evidence of previous occupational exposure at the smelter from measurement of K-Cd.