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Ki-67 is a strong prognostic marker of non-small cell lung cancer when tissue heterogeneity is considered

✍ Scribed by Tabata, Kazuhiro; Tanaka, Tomonori; Hayashi, Tomayoshi; Hori, Takashi; Nunomura, Sayuri; Yonezawa, Suguru; Fukuoka, Junya

Book ID: 125400083
Publisher: BioMed Central
Year: 2014
Tongue: English
Weight: 748 KB
Volume: 14
Category: Article
ISSN: 1472-6890
DOI: 10.1186/1472-6890-14-23

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## Abstract Aberrant methylation of several tumor suppressor genes often occurs during the pathogenesis of lung cancer. RASSF1A is one of the tumor suppressor genes, and it is frequently inactivated by hypermethylation of its promoter region in a variety of human cancers, including lung cancer. It