Ki-1—positive lymphoma developing 10 years after the diagnosis of hairy cell leukemia

✍ Scribed by Susan L. Abbondanzo; Laura E. Sulak

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 636 KB
• Volume: 67
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19910615)67:12<3117::aid-cncr2820671229>3.0.co;2-5

✦ Synopsis

The case is described of a 62-year-old man with a 10-year history of hairy cell leukemia (HCL) who subsequently had a large-cell anaplastic or so-called Ki-lpositive lymphoma. Immunocytochemical staining of the lymphomatous node revealed positivity for Ki-1 (CD30) and epithelial membrane antigen in the tumor cells, and flow cytometric analysis showed simultaneous expression of Leu M5 (CDllc) and Leu 14 (CD22). Although HCL has been reported to coexist with both Hodgkin's disease and non-Hodgkin's lymphoma, the authors believe this is the first case in which a Ki-1-positive lymphoma developed in a patient with HCL. The clinicopathologic and immunologic features of both entities are discussed, as is the association of HCL with other neoplasms. Cancer 67:3117-3122,1991.

AIRY CELL LEUKEMIA (HCL) is a chronic lympho-H proliferative disorder of B-cell origin, which typically occurs in middle-aged men.' Although a minority of HCL patients die early in the course of their disease, many patients survive several years without significant complications after splenectomy as the only treatment.2 The occurrence, however, of a second malignancy is a well-described feature of HCL.3-24 In this report, we describe the development of an anaplastic large cell lymphoma, with a Ki-1-positive phenotype, in a patient in whom the diagnosis of HCL had been made 10 years previously. Flow cytometric analysis of the tumor cells revealed simultaneous expression of Leu M5 (CD1 lc) and Leu 14 (CD22), a pattern considered to be diagnostic for HCL.25 These findings reflect a B-cell lineage for both