KHSV− EBV− post-transplant effusion lymphoma with plasmablastic features: variant of primary effusion lymphoma?

✍ Scribed by Jennifer S. Lambe; Darryl A. Oble; Subhadra V. Nandula; Deborah W. Sevilla; Adriana I. Colovai; Mahesh Mansukhani; Ajai Chari; Vundavalli V. Murty; Bachir Alobeid; Govind Bhagat

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 218 KB
• Volume: 27
• Category: Article
• ISSN: 0278-0232
• DOI: 10.1002/hon.892

✦ Synopsis

Abstract

Primary effusion lymphoma (PEL) is a rare type of B‐cell non‐Hodgkin lymphoma (NHL), which predominantly occurs in HIV‐infected individuals, and is pathogenetically linked with Kaposi sarcoma (KS)‐associated herpes virus/human herpes virus‐8 (KSHV/HHV‐8) infection with or without evidence of Epstein–Barr virus (EBV) co‐infection. Although uncommon, PELs have been reported in immunocompetent patients and recipients of solid organ allografts. Rare cases of KSHV^−^ EBV^+^ post‐transplant effusion lymphomas resembling PEL have also been described, as have KSHV^−^ EBV^−^ effusion lymphomas, the latter including those arising in individuals with chronic liver disease. We report a unique KSHV^−^ EBV^−^ post‐transplant effusion lymphoma associated with serum paraproteins, occurring in an HIV^−^ individual, which had cytologic features and phenotype similar to PEL, and displayed a complex karyotype including isochromosome 12p and translocation t(8;22), resulting in rearrangement of c‐MYC. Copyright © 2009 John Wiley & Sons, Ltd.