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K+/H+ exchange in yeast mitochondria: sensitivity to inhibitors, solubilization and reconstitution of the activity in proteoliposomes

✍ Scribed by Stéphen Manon; Martine Guérin

Book ID
115729951
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
494 KB
Volume
1108
Category
Article
ISSN
0005-2736

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## Abstract Multidrug resistant (MDR) tumor cells exhibit an altered pH gradient across different cell compartments, which favors a reduced intracellular accumulation of antineoplastic drugs and a decreased therapeutic effect. In our study, we have observed that the activity and expression of Na^+^