Keynote review: The adipocyte as a drug discovery target
โ Scribed by Andrea R. Nawrocki; Philipp E. Scherer
- Book ID
- 114385176
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 512 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1359-6446
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme of __de novo__ purine nucleotide biosynthesis and is viewed as an important target in the quest for discovery of drugs in the antiviral, antibacterial and anticancer therapeutic areas. This review focuses on the medicinal chemi
Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are responsible for tumor regrowth and disease relapse. Bmi-1 plays a critical role in the self-renewal of adult stem cells. The Bmi-1 protein is elevated in many types of cancers, and experimental reduction of Bmi-1 pr