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Key factors in the regulation of fetal and postnatal leydig cell development

✍ Scribed by Xiufeng Wu; Shengqin Wan; Mary M. Lee

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 110 KB
Volume: 213
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21231

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The primary function of testicular Leydig cells is the production of androgens to promote sexual differentiation in the fetus, secondary sexual maturation at puberty, and spermatogenesis in the adult. The fetal and postnatal (adult) populations of Leydig cells differ morphologically and have distinct profiles of gene expression. As postnatal Leydig cells differentiate, they transition through three discrete maturational stages characterized by decreasing proliferative rate and increasing testosterone biosynthetic capacity. In this review, we discuss the development of both fetal and postnatal Leydig cells and review the regulation of this process by some of the key hormones and growth factors. J. Cell. Physiol. 213: 429–433, 2007. © 2007 Wiley‐Liss, Inc.

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