## Abstract The development of special methods of bone marrow transplantation, coupled with new knowledge in the area of donorβrecipient selection and the suppression of the secondary diseases, has generated renewed interest in allografting of bone marrow for a variety of diseases. The interest in
Kettering award lecture. The role of marrow transplantation in the eradication of malignant disease
β Scribed by E. Donnall Thomas
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 716 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0008-543X
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Background. Bone marrow transplantation (BMT) patients frequently develop lifethreatening problems that have similar clinical presentations but differing aetiologies. Despite intensive investigation by haematological, biochemical, and microbiological means, accurate diagnosis is not always possible.
Nineteen patients with advanced malignant tumors, less than 20 years old were treated with intensive chemotherapy (vincristine 2 mg/m2 i.v. and adriamycin 60 mg/m2 i.v. on day - 7; cyclophosphamide 45 mg/kg i.v. on days -6 to -3), total body irradiation (TBI, 600 rads on day -1) and autologous bone