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Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling

โœ Scribed by T. K. FOSSE; P. L. TOUTAIN; C. SPADAVECCHIA; H. A. HAGA; T. E. HORSBERG; B. RANHEIM


Book ID
108885559
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
381 KB
Volume
34
Category
Article
ISSN
0140-7783

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โœ Jong Hwan Sung; Anjali Dhiman; Michael L. Shuler ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 295 KB

A combined pharmacokinetic-pharmacodynamic model was developed to simulate the response of a rat tumor to UFT, a combination of uracil with Tegafur (FT). Tegafur is oral the prodrug of 5-fluorouracil (5-FU), an anti-cancer drug for colon cancer. A physiologically based pharmacokinetic (PBPK) model w