✦ LIBER ✦
Keto acids in tissues and biological fluids: O-t-butyldimethylsilyl quinoxalinols as derivatives for sensitive gas chromatographic/mass spectrometric determination
✍ Scribed by U. Langenbeck; H. Luthe; Gritta Schaper
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 293 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1076-5174
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✦ Synopsis
Quinoxalinol t-butyldimethylsilyl ethers were prepared from three branched-chain and from two aliphatic unbranched 2-keto acids. The electrou impact (EL) mass spectra display pronounced [M-57]+ ions. With 39-51'/0 of total ion current contained within them, sensitivity is greater than on chemical ionization (CI) mass spectrometry of 0-trimethylsilyl derivatives. Mass spectra and chromatographic behaviour of these novel keto acid derivatives are discussed and preliminary quantitative data from rat muscle are given.