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Ketene bis(trimethylsilyl) acetals. Cross-aldol condensation with aldehydes. Stereochemistry of the reaction

✍ Scribed by Jacques-Emile Dubois; Georges Axiotis; Emmanuel Bertounesque

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
270 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

enolsilanes 1 does not govern the stereochemistry of aldol condensation products. We recently reported for the first time', acetals la6'8, that compounds 2, structural analogous of add to aldehydes and Schiff bases in a cross-aldol type condensation, to afford B-hydroxyacids and B-Lactams respectively, with good yields. Continuing our investigations in this field, we report in this paper the stereochemical outcome of the reaction of enolate pro-chira1 equivalents Ib with aldehydes in the presente of titanium tetrachloride. This study makes -

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